Massive Penicillin Doses

Keratoderma blenorrhagica following Reiter's disease; report of a case successfully treated with massive doses of penicillin.

A man aged 43 years, who was admitted to this hospital on Aug. 23, 1947, said that he had been quite well until 1938 when he was taken ill and treated in Coventry Hospital for acute rheumatism. Questioning, however, disclosed that the illness had consisted of conjunctivitis, -polyarthritis, and fever; there was no history of urethritis. After a year or so in hospital he was discharged with a co...

Prolonged delirium tremens requiring massive doses of medication.

Delirium tremens might last for weeks and treatment requires massive benzodiazepine doses, yet it is possible to manage patients with this condition successfully. In this case of delirium tremens, standard agents at the usual recommended doses were not sufficient to achieve control of confusion and agitation or to stabilize neurologic and cardiovascular parameters. The patient required extraord...

Massive doses of steroids in cryogenic cerebral injury and edema.

Cryogenic lesions were produced in the brains of rhesus monkeys and the accompanying edema measured by quantitative chemical methods. No effect on this type of edema could be demonstrated in animals treated with massive doses of steroids.

Effects of massive doses of methylcholanthrene on epidermal carcinogenesis.

In the production of carcinoma of the skin in mice methylcholanthrene is usually applied several times a week in a 0.3 to 0.6 per cent solution in benzene. Its toxicity is often manifest locally by necrosis of the epidermal cells and ulceration; systemically by a decrease in body weight. These changes are more frequently seen in animals subjected to larger doses of methylcholanthrene. According...

Massive Doses of Sulfones For Treatment of Foot-Rot